Miodrag Stojkovic

Personal Information

Date of birth                                      05/07/1964

Place of birth                                     Leskovac, Serbia


Spoken and/or written languages    English, German, Macedonian and Serbian (mother language).

Citizenships                                      Serbian and German.

Other information                             Married, mobile and ready to be relocated after three months period of notice.

Career Objective      

To progress, to surpass, and to establish myself in a dynamic organization where my experiences, my engagement and my academic background provide me to make a positive contribution to your institution.

Professional Experiences

April 2008     Founder of Spebo and Spebo Medical, IVF clinic, Leskovac, Serbia

Jan. 2007      Professor, Human Genetics, Medical School, University of Kragujevac, Serbia

Jan. 2006-March 2010            Deputy Director. Príncipe Felipe Centro de Investigación (CIPF), Valencia, Spain

Aug. 2005     Chair (Professor) - Embryology and Stem Cell Biology, Responsible for derivation, characterisation, differentiation and application of human embryonic stem cells,

Centre for Stem Cell Biology and Developmental Genetics, Institute of Human Genetics, University of Newcastle, Newcastle upon Tyne, UK

Sep. 2004     Deputy Director of Centre for Stem Cell Biology and Developmental Genetics, University of Newcastle

Dec. 2003     University Reader in Embryology and Stem Cell Biology, Medical School, Institute of Human Genetics, University of Newcastle

Oct. 2002     Senior Research Embryologist and Senior Research Associate, Newcastle Fertility Centre at Life (NHS), International Centre for Life, Newcastle

July 2002      C2 position-Private Docent, Head of the IVF Laboratory, Department of Molecular Animal Breeding and Biotechnology, Ludwig Maximilian’s University (LMU), Munich, Germany

Nov. 1998     C1 position, Post-Doctoral Fellow, Head of the IVF Laboratory, Department of Molecular Animal Breeding and Biotechnology, LMU, Munich

Sept. 1995    Post-Doctoral Fellow, Responsible for in vitro production of animal embryos, Department of Molecular Animal Breeding and Biotechnology,  LMU, Munich

Other Experiences and Achievements                                                                                                                      

Jan. 2010         Member of Serbian public radio and television program board

Sept. 2009       Award Serbian Physiological Society

July 2009         Editor of STEM CELLS

July 2009         Member of Executive Committee European Society for Human Reproduction (ESHRE)

Sept. 2008       Member of ESHRE

Nov. 2007       COCEMFE Award, Valencia, Spain

Mai 2006         Award ‘Braca Karic’ Serbia

Feb. 2006        Founding member of the European Society for Regenerative Medicine (ESRM)

Dec. 2004        Honorary citizen of Leskovac, Serbia

Aug. 2004       First license granted to use nuclear transfer embryos to derive human embryos for derivation of nuclear transfer stem cells

July 2004         TIME magazine: One of 12 global tech influentials

Jan. 2001         Founding Diplomat of the European College of Animal Reproduction (ECAR)

June 2000        Organizer of the International Reproductive Meeting, ARTA in Jena, Germany

June 2000        Winner of the International ARTA award in Jena

Jan. 1995-now             Supervisor of 8 Post-docs, 14 PhD students and 9 technical assistants

Conduct and perform                                                                                                        

Derivation, growth, differentiation, and transplantation of human embryonic and adult stem cells (spinal cord injury model)

Nuclear transfer technique

In vitro production and micromanipulation of

mammalian gametes and embryos

Biology of mammalian embryos and stem cells

Reprogramming of adult cells

1991 to 1993   University Hospital of Hamburg, Eppendorf (Germany)

Male Nurse: Assured patient’s care and medication and treated pre and post operation patients.

1990 to 1991   Pharmaceutical Institute Zdravlje, Leskovac, Former Yugoslavia

Researcher: Investigated and examined new medications (absorption and exsorption).

Academic Formation                                                                             

Jan. 2007         Professor, Human Genetics, Medical School, University of Kragujevac, Serbia

April 2006       Visiting Professor, Medical Faculty, University of Pristina, Serbia

Nov. 2005       Visiting Professor, Military Medical Academy (VMA), Belgrade, Serbia

Aug. 2005       Chair (Professor) in Embryology and Stem Cell Biology, Medical school, Centre for Stem Cell Biology and Developmental Genetics, University of Newcastle, Newcastle upon Tyne, UK

July 2005         Visiting Professor, Medical Faculty, University of Kragujevac, Serbia

Dec. 2003        Readership in Embryology and Stem Cell Biology, Institute of Human Genetics, University of Newcastle

Apr. 2003        Honorary Research Associate in the School of Surgical and Reproductive Sciences, Faculty of Medical Sciences, University of Newcastle

July 2002         Habilitation (private Docent), Animal Breeding and Biotechnology, Faculty of Veterinary Medicine, LMU Munich, Germany, Department of Molecular Animal Breeding and Biotechnology, Munich, Germany

1993-1996       PhD Study Thesis: In vitro Production of Bovine Embryos and Trophoblastic Tissue, Prof. Dr. E. Wolf, Veterinary Medicine Equivalent Study LMU, Munich

1984-1990       Veterinary Medicine Diploma, University of Belgrade, former Yugoslavia

1981-1983       Male Nurse Diploma, Nursing School, former Yugoslavia

Grants and funding:                                                                                                                

Funding of €6.000,000 by Spanish CONSOLIDAR. Collaborative project. The Spanish ion channel initiative. Antonio Ferrer Montiel (CO), José Manuel González Ros, Manuel Criado, José Luis Neira, Rosa Planells Cases, Enrique Pérez Payá, Vicente Felipo, Miodrag Stojkovic, Andrés Morales, Rafael Luján Miras, Diego Álvarez de la Rosa, Isabel Pérez Otaño, Pilar de la Peña, José A. Lamas, Luis Carlos Barrios Calvo, Diego M.A. Guérin, Rosario González Muñiz, Àngel Messeguer Peypoch, Luis Alfonso de la Cruz, Oscar Millet, Antonio Felipe Campos, Antonio Rodríguez Artalejo, Maria T. Miras Portugal, Ricardo Borges, Alvaro Villarroel, Francisco Ciruela. 

Funding of €2.999,879 by EU, FP7. Collaborative Project, HEALTH-2007-1.4-7: Development of stem cell culture conditions. LIV-ES, A. Weber (CO), G. Uzan, C. Guillouzo, R. Pederson, L. Vallier, E. Galun, M. Stojkovic, D. Burks, P. Bouillé, T. Tuuri, A. Urti. (approved).

Funding of €217,800 by Ministerio de Educación y Ciencia, Spain: The use of stem cell derived neural progenitors in cell replacement therapy. M. Stojkovic. 01/07/2007-01/07/2010.

Funding of €270,000 by Fondation for Development of Serbia: Establishment of IVF clinic and stem cell research. M. Stojkovic

Funding of €120,000 by National Investment Program, Serbia: Establishment of IVF clinic and stem cell research. M. Stojkovic 01/02/2008

Funding of €67,000 by Instituto de Salud Carlos III (Red temática de investigación cooperativa en Salud). C. Simon, M. Stojkovic. 06/11/2007-06/11/2008.

Funding of £261,010 by MRC, UK, Project Grant: Avoiding conflict of interest between IVF and research scientists in human embryonic stem cell derivation.  A. Murdoch, E. Heimes, M Herbert, M. Stojkovic, M. Lako, T. Strachan. 01/04/2004-31/03/2007.

Funding of £60,000 Discretionary Fund, University of Newcastle, UK: Derivation of hES cell lines. M. Stojkovic. 20/02/2004

Funding of £75,000 by OneNorth East Regional Developmental Agency, Project Grant. Improvement of conditions for culture of hESC.  T. Strachan, M. Stojkovic, M. Lako. 01/06/2003-31/05/2004. 

Funding of £312,000 by BBRSC Project Grant: Impacts of TERT expression on the characteristics of hESC. M. Lako, T. Strachan, M. Stojkovic, N. Hole, S. Przyborski. 1/04/2004-31/03/2007.

Funding of £210,032 by MRC, UK, Strategic Grant: Towards derivation of clinical-grade hESC lines. M. Stojkovic, M. Lako, A. Murdoch, T. Strachan. 31/03/2004-31/03/2007.

Funding of £140,000 by LRF, Project Grant: Investigation of the haematopoietic differentiation of human ES cells. M. Lako, M. Stojkovic, T. Strachan, L. Forrester. 01/08/2004-31/07/2007.

Funding of £255,000 University of Newcastle, UK: Derivation of NT-embryos. M. Stojkovic. 15/09/2004.

Funding of £75,000 Medical School, University of Newcastle, UK: hESC biology. M. Lako and M. Stojkovic. 08/10/2004.

Funding of £187,000 CELS, Newcastle upon Tyne: Equipment grant. Small item equipment for refurbished new stem cell facilities. M. Stojkovic and M. Lako

Funding of £60,000 by OneNorth East Regional Developmental Agency. Consumables for characterisation and differentiation of hESC. M. Stojkovic and M. Lako. 17/01/2005-31/03/2005.

Funding of £1,400. Undergraduate Research Bursaries. The Nuffield Foundation. M. Stojkovic and L. Pascoe.

Funding of £56,000 by OneNorth East Regional Developmental Agency. Equipment grant. M. Stojkovic and M. Lako. 18/07/2005.

Leisure’s and Interests

Leisure’s:       ‘Side views’

Interests:        Dogs, films, and classical music

List of Publications                                                                                 

Stojkovic M, Wolf E, Büttner M, Berg U, Charpigny G, Schmitt A, Brem, G (1995). Secretion of biologically active interferon tau by in vitro-derived bovine trophoblastic tissu

e. Biol Reprod 53: 1500-1507.

Stojkovic M, Wolf E, Van Langendonckt A, Vansteenbrugge A, Charpigny G, Reinaud P, Gandolfi F, Brevini TAL, Mermillod P, Terqui M, Brem G, Massip, A (1997). Correlation between chemical parameters, mitogenic activity, and embryotrophic activity of bovine oviduct-conditioned medium. Theriogenology 48: 659-673.

Zakhartchenko V, Stojkovic M, Brem G, Wolf E (1997). Karyoplast-cytoplast volume ratio in bovine nuclear transfer embryos: effect on the developmental potential. Mol Reprod Dev 48: 332-338.

Wolf E, Stojkovic M, Wenigerkind H, Santl B, Prelle K, Reichenbach HD, Zakhartchenko V, Schernthaner W, Palma GA, Brem G (1997). Some factors affecting efficiency of in vitro production of bovine embryos and related techniques. In N. Li & Y. Chen (Eds.), (pp. 285-291). Beijing: International Academic publishers (book chapter).

Stojkovic M, Zakhartchenko V, Brem G, Wolf E (1997). Support for the development of bovine embryos in vitro by secretions of bovine trophoblastic vesicles derived in vitro. J Reprod Fertil 111(2): 191-196.

Stojkovic M, Büttner M, Zakhartchenko V, Brem G, Wolf E (1998). A reliable procedure for differential staining of in vitro produced bovine blastocysts: comparison of Tissue culture Medium 199 and Menezo's B2 medium. Anim Reprod Sci 50: 1-9.

Kölle S, Sinowatz F, Boie G, Palma GA, Stojkovic M, Wolf E (1998). Topography of growth hormone receptor expression in the bovine embryo. Histochem Cell Biol 109: 417-419.

Santl B, Wenigerkind H, Schernthaner W, Mödl J, Stojkovic M, Prelle K, Holtz W, Brem G, Wolf E (1998). Comparison of ultrasound-guided vs laparascopic transvaginal ovum pick-up (OPU) in simmental heifers. Theriogenology 50: 89-100.

Bieser B, Stojkovic M, Wolf E, Meyer H, Einspanier R (1998). Growth factors and components for extracellular proteolysis are differentially expressed during in vitro maturation of bovine cumulus-oocyte complexes. Biol Reprod 59: 801-806.

Durcova-Hills G, Prelle K, Müller S, Stojkovic M, Motlik J, Wolf E, Brem G (1998). Primary culture of porcine PGCs requires LIF and porcine membrane bound stem cell factor. Zygote 6: 271-275.

Schernthaner W, Wenigerkind H, Stojkovic M, Palma GA, Mödl J, Wolf E, Brem G (1999). Pregnancy rate after ultrasound-guided follicle aspiration in nonlacting cows from different breeds. J Vet Med 46: 33-37.

Zakhartchenko V, Durcova-Hills G, Schernthaner W, Stojkovic M, Reichenbach HD, Müller S, Prelle K, Steinborn R, Müller M, Wolf E, Brem G (1999). Potential of fetal germ cell for nuclear transfer in cattle. Mol Reprod Dev 52: 421-426.

Zakhartchenko V, Durcova-Hills G, Stojkovic M, Schernthaner W, Prelle K, Steinborn R, Müller M, Brem G, Wolf, E (1999). Effects of serum starvation and re-cloning in the efficiency of nuclear transfer using bovine foetal fibroblasts. J Reprod Fertil 115: 325-331.

Stojkovic M, Büttner M, Zakhartchenko V, Riedl J, Reichenbach HD, Wenigerkind H, Brem G, Wolf E (1999). Secretion of interferon-tau by bovine embryos in long-term culture: comparison of in vivo derived, in vitro produced, nuclear transfer and demi embryos. Anim Reprod Sci 55: 151-162.

Stojkovic M, Motlik J, Kölle S, Zakhartchenko V, Alberio R, Sinowatz F, Wolf E (1999). Cell-cycle control and oocyte maturation: review of literature. Reprod Dom Anim 34: 335-342.

Stojkovic M, Zakhartchenko V, Wolf E (1999). In vitro culture of bovine embryos: from co-culture to the serum-free media with the same efficiency. Mac J Reprod 5(2): 119-128.

Stojkovic M, Westesen K, Zakhartchenko V, Stojkovic P, Boxhammer K, Wolf E (1999). Coenzyme Q10 in submicron-size dispersion improves development, cell proliferation, and hatching of in vitro produced bovine embryos. Biol Reprod 61: 541-547.

Zakhartchenko V, Alberio R, Stojkovic M, Prelle K, Schernthaner W, Stojkovic P,

Wenigerkind H, Wanke R, Duchler M, Steinborn R, Brem G, Wolf E (1999). Adult cloning in cattle: Potential of nuclei from a permanent cell line and from primary cultures. Mol Reprod Dev 54: 264-272.

Alberio R, Palma GA, Stojkovic M, Brem G, Wolf E (1999). Effects and interactions of bovine growth hormone with FSH on the kinetics of nuclear maturation of bovine oocytes and development of in vitro produced embryos. Mac J Reprod 5(2): 129-137.

Alberio R, Motlik J, Stojkovic M, Wolf E, Zakhartchenko V (2000). Behavior of M-phase synchronized blastomeres after nuclear transfer in cattle. Mol Reprod Dev 57: 37-47.

Suttner R, Zakhartchenko V, Stojkovic P, Müller S, Alberio R, Brem G, Wolf E, Stojkovic M (2000). Intracytoplasmic sperm injection in bovine: effects of oocyte activation, sperm pre-treatment and injection technique. Theriogenology 54: 935-948.

Steinborn R, Schinogl P, Zakhartchenko V, Achmann R, Schernthaner W, Stojkovic M, Wolf E, Muller M, Brem G (2000). Mitochondrial DNA heteroplasmy in cloned cattle produced by fetal and adult cell cloning. Nature Genet 25: 255-257.

Wolf E, Schernthaner W, Zakharchenko V, Prelle K, Stojkovic M, Brem G (2000). Transgenic technology in farm animals – progress and perspectives. Exp Physiol 85.6: 615-625.

Laurincik J, ZakhartchenkoV, Avery B, Stojkovic M, Brem G, Wolf E, Müller M, Hyttel P (2000). Activation of ribosomal RNA genes in pre-implantation in vitro produced and nuclear transfer bovine embryos. Reprod Dom Anim 35: 255-259.

Hyttel P, Laurincik J, Zakhartchenko V, Stojkovic M, Wolf E, Müller M, Ochs RL, Brem G (2001). Nucleolar protein allocation and ultrastructure in bovine embryos produced by nuclear transfer from embryonic cells. Cloning 3: 69-82.

Stojkovic M, Machado SA, Stojkovic P, Zakhartchenko V, Hutzler P, Goncalves PB, Wolf E (2001). Mitochondrial distribution and adenosine triphosphate content of bovine oocytes before and after in vitro maturation: correlation with morphological criteria and developmental capacity after in vitro fertilization and culture. Biol Reprod 64: 904-909.

Prelle K*, Stojkovic M*, Boxhammer K, Motlik J, Ewald D, Arnold GJ, Wolf E (2001). IGF-I and Long R3-IGF-I differently affect development and messenger RNA abundance for IGF-binding proteins and Type I IGF receptors in in vitro produced bovine embryos. Endocrinology  142(9): 1309-1316 (*these two authors equally contributed to the study).

Stojkovic M, Kölle S, Zakhartchenko V, Stojkovic P, Sinowatz F, Wolf E (2001): Effects of estrous cow serum/bovine serum albumin on early cleavage, blastocyst rate, cell number, and ultrastructural configuration of in vitro produced bovine embryos. Adv Reprod V: 35-44.

Stojkovic M, Kölle S, Zakhartchenko V, Stojkovic P, Sinowatz F, Wolf E (2001): Effects of estrous cow serum/bovine serum albumin on early cleavage, blastocyst rate, cell number, and ultrastructural configuration of in vitro produced bovine embryos. Adv Reprod V: 35-44.

Kölle S, Stojkovic M, Prelle K, Waters M, Wolf E, Sinowatz F (2001). Developmental expression and action of growth hormone and its receptor in bovine IVF embryos. Biol Reprod 64: 1826-1834.

Freistedt P, Stojkovic M, Wolf E (2001). Efficient in vitro production of cat embryos in modified synthetic oviduct fluid medium: effects of season and ovarian status. Biol Reprod 65: 301-305.

Freistedt P, Stojkovic P, Wolf E, Stojkovic M (2001). ATP-content of non-matured and in vitro matured domestic cat oocytes and different stages of in vitro produced embryos: effects of assisted hatching treatment on the ATP-content and total cell number. Biol Reprod 65: 793-798.

Zakhartchenko V, Müller S, Alberio R, Schernthaner W, Stojkovic M, Wenigerkind H, Wanke R, Müller M, Wolf E, Brem G (2001). Nuclear transfer in cattle with non-transfected and transfected fetal or cloned transgenic fetal and postnatal fibroblast. Mol Reprod Dev 60: 362-369.

Dean W, Santos F, Stojkovic M, Zakhartchenko V, Walter J, Wolf E, Reik W (2001). Conservation of methylation reprogramming in mammalian embryos: aberrant reprogramming in cloned embryos. Proc Natl Acad Sci USA 98(24): 13734-13738.

Brüggerhoff K, Zakhartchenko V, Wenigerkind H, Reichenbach HD, Prelle K, Schernthaner W, Alberio R, Küchenhoff H, Stojkovic M, Hiendleder S, Wolf E (2002). Bovine somatic cell nuclear transfer using recipient oocytes recovered by ovum pick-up: effect of donor mitochondrial genotype. Biol Reprod 66: 367-373.

Kölle S, Stojkovic M, Boie G, Wolf E, Sinowatz F (2002). Growth hormone inhibits apoptosis in in vitro produced bovine embryos. Mol Reprod Dev 61: 180-186.

Laurincik J, Zakhartchenko V, Stojkovic M, Brem G, Wolf E, Müller M, Ochs RL, Madox-Hyttel P (2002). Nucleolar protein allocation and ultrastructure in bovine embryos produced by nuclear transfer from granulosa cells. Mol Reprod Dev 61: 477-487.

Einspanier R, Schönfelder M, Müller K, Stojkovic M, Kosmann M, Wolf E, Schams D (2002). Expression of the vascular endothelial growth factor and its receptors and effects of VEGF during in vitro maturation of bovine cumulus oocyte complexes (COC). Mol Reprod Dev 62: 29-36.

Stojkovic M, Kölle S, Peinl S, Stojkovic P, Zakhartchenko V, Thompson JG, Wenigerkind H, Reichenbach H-D, Sinowatz F, E Wolf (2002). Effects of high concentration of hyaluronan in culture medium on development and survival rates of fresh and frozen/thawed in vitro produced bovine embryos. Reproduction 124(1): 141-153.

Rief S, Sinowatz F, Stojkovic M, Einspanier R, Wolf E, Prelle K (2002). Establishment of a co-culture system with oviductal cells that affects development, energy metabolism and gene expression of in vitro produced bovine embryos. Reproduction 124(4): 543-556.  

Motlik J, Alberio R, Zakhartchenko V, Stojkovic M, Kubelka M, Wolf E (2002). The effect of activation of mammalian oocytes on remodelling of donor nuclei after nuclear transfer. Cloning Stem Cells 4(3): 245-252.

Stojkovic M, Krebs O, Kölle S, Prelle K, Assmann V, Zakhartchenko V, Sinowatz F, Wolf E (2003). Developmental regulation of hyaluronan-binding protein (RHAMM/IHABP) expression in early bovine embryos. Biol Reprod 68: 60-66.

Hiendleder S, Zakhartchenko V, Wenigerkind H, Reichenbach HD, Brüggerhoff K, Prelle K,Brem G, Stojkovic M, Wolf E (2003). Heteroplasmy in bovine fetuses produced by intra- and inter-subspecific somatic cell nuclear transfer: Neutral segregation of nuclear donor mitochondrial DNA in various tissues and evidence for recipient cow mitochondria in fetal blood. Biol Reprod 68: 159-166.

Laurincik J, Schmoll F, Mahabir E, Schneider H, Stojkovic M, Zakhartchenko V, Prelle K, Hendrixen PJM, Voss PLAM, Moeszlacher GG, Avery B, Dieleman SJ, Besenfelder U, Müller M, Ochs RL, Wolf E, Schellander K and Maddox-Hyttel P (2003). Nucleolar proteins and ultrastructure in bovine in vivo developed in vitro produced and parthenogenetic cleavage-stage embryos. Mol Reprod Dev, 65: 73-85.

Kölle S, Stojkovic M, Boie G, Wolf E, Sinowatz F (2003). Growth hormone-related effects on apoptosis, mitosis and expression of connexin-43 in in vitro matured bovine cumulus-oocyte-complexes. Biol Reprod 68: 1584-1589.

Wei S, Höflich A, Flaswinkel H, Stojkovic M, Wolf E, Zakhartchenko V (2003). Induction of senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear-transfer embryos. Biol Reprod, 69: 301-309.

Santos F, Zakhartchenko V, Stojkovic M, Peters A, Jenuwein T, Wolf E, Reik W, Dean W (2003). Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos. Curr Biol, 13: 1116-1121.

Wolf E, Arnold GJ, Bauersachs S, Beier HM, Blum H, Einspanier R, Fröhlich T, Herrler A, Hiendleder S, Kölle S, Prelle K, Reichenbach H-D, Stojkovic M, Wenigerkind H, Sinowatz F (2003). Embryo-maternal communication in bovine – strategies for deciphering a complex cross-talk. Reprod Dom Anim 38(4): 276-289.

Hofmann A, Kessler B, Ewerling S, Weppert M, Vogg B, Ludwig H, Stojkovic M, Boelhauve M, Brem G, Wolf E, Pfeifer A (2003). Efficient transgenesis in farm animals by lentiviral vectors. EMBO Rep. 4: 1054-1058.

Hiendleder S, Prelle K, Brüggerhoff K, Reichenbach H-D, Wenigerkind H, Bebbere D, Stojkovic M, Müller S, Brem G, Zakhartchenko V, Wolf E (2004). Nuclear-cytoplasmic interactions affect in utero developmental capacity, phenotype and cellular metabolism of bovine nuclear transfer fetuses. Biol Reprod 70: 1196-1205.

Kolle S, Stojkovic M, Reese S, Reichenbach HD, Wolf E, Sinowatz F (2004) Effects of growth hormone on the ultrastructure of bovine preimplantation embryos. Cell Tiss Res 317: 101-108.

Tamassia M, Nuttinck F, May-Panloup, Heyman Y, Charpigny, Stojkovic M, Wolf E, Reynier P, Renard J-P, Chastant-Mailard S (2004). Characterization of the mitochondrial DNA control region, quantification of mitochondrial DNA and ATP contents of oocytes from cows with different developmental abilities for blastocyst production. Biol Reprod 71: 697-704. 

Stojkovic M, Lako L, Strachan T, Murdoch AP (2004). Derivation and characterisation of human embryonic stem cells. Reproduction 128: 259-267.

Stojkovic M, Lako M, Stojkovic P, Stewart R, Przyborski S, Armstrong L, Evans J, Herbert M, Hyslop L, Ahmad S, Murdoch A, Strachan T (2004). Derivation of human embryonic stem cells from Day 8 blastocysts recovered after three-steps in vitro culture. STEM CELLS 22: 790-797.

Choudhary M, Haimes E, Herbert M, Stojkovic M, Murdoch AP (2004). Demographic, medical and treatment characteristics associated with couples' decisions to donate fresh spare embryos for research. Hum Reprod 19:2091-2096.

Armstrong L, Stojkovic M, Dimmick I, Ahmad S, Stojkovic P, Hole N, Lako M (2004). Phenotypic investigation of murine haematopoietic progenitors isolated on basis of aldehyde dehydrogenase activity. STEM CELLS 22:1142-1151.

Stojkovic P, Lako M, Stewart R, Przyborski S, Armstrong L, Evans J, Murdoch AP, Strachan T, Stojkovic M (2005). An autogeneic feeder-system that efficiently supports undifferentiated growth of human embryonic stem cells. STEM CELLS 23: 306-314.

Stojkovic P, Lako M, Armstrong L, Stojkovic M (2005). Human embryonic stem cells express markers of pluripotency and differentiate under long-term in vitro growth conditions. Medicus 6: 6-10.

Stojkovic P, Lako M, Przyborski S, Stewart R, Armstrong L, Evans J, Zhang X, Stojkovic M (2005). Human-serum matrix supports undifferentiated growth of undifferentiated human embryonic stem cells. STEM CELLS 23: 895-902.

Stojkovic M, Stojkovic P, Leary C, Hall VJ, Armstrong L, Herbert M, Nesbitt M, Lako M, Murdoch A (2005). Derivation of a human blastocyst after heterologous nuclear transfer to donated oocytes. RBM Online 11: 226-231.

Hyslop LA, Stojkovic M, Armstrong L, Walter T, Stojkovic P, Przyborski S, Herbert  M, Murdoch A, Strachan T, Lako M (2005). Downregulation of NANOG results in differentiation of human ES cells to extraembryonic lineages. STEM CELLS 23: 1035-1043.

Hyslop LA, Armstrong L, Stojkovic M, Lako M (2005). Human embryonic stem cell biology and clinical implications. Expert Rev Mol Med 7: 1-21.

Emanueli C, Lako M, Stojkovic M, Madeddu P (2005). In search of the best candidate for regeneration of ischemic tissues: Are embryonic/fetal stem cells more advantageous than adult counterparts? Thromb Haemost 94: 738-749.

Heng BC, Tong GQ, Stojkovic M (2006). The egg-sharing model for human therapeutic cloning. Managing donor selection criteria, the proportion of shared gametes allocated to research, and amount of financial subsidy given to the donor. Med. Hypotheses 66: 1022-1024.

Cooke M, Stojkovic M, Przyborski S (2006). Growth of teratomas derived from human pluripotent stem cells is influenced by the anatomical location of the graft site. Stem Cells and Development 2: 254-259.

Armstrong L, Lako M, Dean W, Stojkovic M (2006). Epigenetic modification is central to genome reprogramming in somatic cell nuclear transfer. STEM CELLS 4: 805-814.

Armstrong L, Hughes O, Young S, Hyslop L, Stewart R, Wappler I, Peters H, Walter T, Stojkovic P, Evans J, Stojkovic M, Lako M (2006). The role of PI3K/AKT, MAPK/ERK and NF?ß signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis. Hum Mol Genet 15: 1894-1913.

Hall V, Stojkovic M (2006). The status of human nuclear transfer. Stem Cell Rev 2: 301-308.

Heng BC, Stojkovic M, Vajta G, Cao T (2006). Mammalian oocyte polarity can be exploited for the automation of somatic cell nuclear transfer - in the development of a 'cloning biochip'. Med. Hypotheses 67: 420-421.

Stewart R, Stojkovic M, Lako M (2006). Mechanisms of self-renewal in human embryonic stem cells. Eur J Cancer 42: 1257-1272.

Hiendleder S, Wirtz M, Mund C, Klempt M, Reichenbach H-D, Stojkovic M, Weppert M, Wenigerkind H, Elmlinger M, Lyko F, Schmitz OJ, Wolf E (2006). Tissue-specific effects of in vitro fertilization procedures on genomic cytosine methylation levels in overgrown and normal sized bovine fetuses. Biol Reprod 75: 17-23.

Hall V, Stojkovic P, Stojkovic M (2006). Therapeutic cloning to fight human disease: A conundrum or reality? STEM CELLS 24: 1628-1637.

Zhang X, Stojkovic P, Przyborski D, Cooke M, Armstrong L, Lako M, Stojkovic M (2006). Derivation of human embryonic stem cells from developing and arrested embryos. STEM CELLS 24: 2669-2676.

Hall V, Compton D, Stojkovic P, Nesbitt M, Herbert M, Murdoch A, Stojkovic M (2006). Developmental competence of human in vitro aged oocytes as host cells for nuclear transfer. Hum Reprod 22: 52-62.

Stojkovic M (2006). Progress in nuclear transfer technique and embryonic stem cell biology: too fast, to scary? Proceeding of the world congress for freedom of scientific research. Rome. Edited by Chiara Lalli and Carmen Sorrentino. pp155-161.

Hall V, Stojkovic M (2006). Nuclear transfer and its applications in regenerative medicine. Stem Cells in human reproduction, basic science and therapeutic potential. Book chapter (Valles/Pellicer).

Ahmad S, Armstrong L, Stojkovic M, Dimmick I, Hyslop LA, Stojkovic P, Strachan T, Figueiredo FC, Lako M (2007). Differentiation of human embryonic stem cells into corneal epithelial like cells by in vitro replication of the corneal epithelial stem cell niche. STEM CELLS 25: 1145-1155.

Allegrucci C, Wu Y-C, Denning CN, Priddle H, Mummery CL, van Oostwaard D, Andrews PW, Stojkovic M, Smith N, Parkin T, Yu L, Brena MR, Plass C, Young LE (2007). Extensive epigenetic variation in DNA methylation between and within human embryonic stem cell lines. Hum Mol Genet 16: 1253-1268.

Cervera RP, Stojkovic M (2007). Human embryonic stem cell derivation and nuclear transfer: Impact on regenerative therapeutics and drug discovery. Clinical Pharmacology & Therapeutics 82: 310-315. 

Adewumi O, Aflatoonian B, Ahrlund-Richter L, Amit M, Andrews PW, Beighton G, Bello PA, Benvenisty N, Berry LS, Bevan S, Blum B, Brooking J, Chen KG, Choo ABH, Churchill GA, Corbel M, Damjanov I, Draper JS, Dvorak P, Emanuelsson K, Fleck RA, Ford A, Gertow K, Gertsenstein M, Gokhale PJ, Hamilton RS, Hampl A, Healy LE, Hovatta O, Hyllner J, Imreh MP, Itskovitz-Eldor J, Jackson J, Jonson JL, Jones M, Kee K, King BL, Knowles BB, Lako M, Lebrin F, Mallon BS, Manning D, Mayshar Y, Mckay RDG, Michalska AE, Mikkola M, Mileikovsky M, Minger SL, Moore HD, Mummery CL, Nagy A, Nakatsuji N, O’Brien CM, Oh SKW, Olsson C, Otonkoski T, Park K-Y, Passier R, Patel H, Patel M, Pedersen R, Pera MF, Piekarczyk MS, Reijo-Pera RA, Reubinoff BE, Robins AJ, Rossant J, Rugg-Gunn P, Schulz TC, Semb H, Sherrer EC, Siemen H, Stacey GN, Stojkovic M, Suemori H, Szatkiewicz J, Turetsky T, Tuuri T, van den Brink S, Vintersten S, Vuoristo S, Ward D, Weaver TA, Young LA, Zhang W (2007). The international stem cell initiative. Characteristics of human embryonic stem cell lines: results from the International Stem Cell Initiative. Nature Biotechnol 25: 803-816.

Stojkovic M (2007). Current status of somatic cell reprogramming Medicus 8: 39-42.

Choudhary M, Zhang X, Stojkovic P, Hyslop L, Anyfantis G, Herbert M, Murdoch AP, Stojkovic M*, Lako M* (2007). Putative role of hyaluronan and its related genes, HAS2 and RHAMM in human early preimplantation embryogenesis and embryonic stem cell characterization. STEM CELLS 12: 3045-3057. *corresponding authors

Saretzki G, Walter T, Passos JF, Bareth B, Keith WN, Stuart R, Atkinson S,  Hoare S, Stojkovic M, Armstrong L, von Zglinicki T, Lako M (2008). Down-regulation of multiple stress defence mechanisms during differentiation of human embryonic stem cells. STEM CELLS 26: 455-464.

Stojkovic M, Phinney D (2008). Reprogramming battle: egg vs. virus. STEM CELLS 26: 1-2.

Cervera R, Stojkovic M. Somatic Cell Nuclear Transfer-Progress and Promise (2008). STEM CELLS 26: 494-495.

Erceg S, Laínez S, Ronaghi M, Stojkovic P, Pérez-Aragó MA, Moreno-Manzano V, Planells-Cases R, Stojkovic M (2008). Differentiation of human embryonic stem cells to regional specific neural precursors in chemically defined medium conditions. PLoS ONE 3(5):e2122.

Stewart R, Yang C, Anyfantis G, Przyborski S, Hole N, Strachan T, Stojkovic M, Keith WN, Armstrong L, Lako M (2008). Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells. Regen Med 3:505-522. 

Ledran M, Krassowska A, Armstrong L, Dimmick I, Yung S, Dzierzak E, Stojkovic M, Forrester L, Lako M (2008). Efficient haematopoietic differentiation of human embryonic stem cells on stromal cells derived from haematopoietic niches. Cell Stem Cell 3:85-98.

Gorelik J, Ali NN, Abdul Kadir S, Lab M, Stojkovic P, Armstrong L, Sviderskaya EV, Negulyaev YA, Klenerman D, Bennett DC, Lako M, Harding SE, Stojkovic M, Korchev YE (2008). Non-invasive imaging of stem cells by scanning-ion conductance microscopy: future prospective. Tissue Eng Part C 14:311-318.

Tilgner K, Atkinson SP, Golebiewska A, Stojkovic M, Lako M, Armstrong L (2008). Isolation of primordial germ cells from differentiating human embryonic stem cells. STEM CELLS 26:3075-3085.

Stojkovic M, Stojkovic P (2008). A short introduction to markers of stem cells and their neural derivates. Serbian Journal of Experimental and Clinical Research 9: 123-127.

Stojkovic M. Human embryonic stem cells (hESCs): celebrating 10 years of hESC lines (2008). STEM CELLS 26:2746.

Zhang X , Neganova I , Przyborski S , Yang C , Cooke M , Atkinson SP , Anyfantis G , Fenyk S , Keith WN , Hoare SF , Hughes O , Strachan T , Stojkovic M , Hinds PW , Armstrong L , Lako M (2009). A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A. J Cell Biol 184:67-82.

Moreno-Manzano V, Rodríguez-Jiménez J, García-Roselló M, Laínez S, Erceg S, Teresa Calvo M, Ronaghi M, Lloret M, Planells-Cases R, Sánchez-Puelles JM, Stojkovic M (2009). Activated spinal cord ependymal stem cells rescue neurological function STEM CELLS 27: 733-743.

Erceg S, Ronaghi M, Stojkovic M (2009). Human embryonic stem cell differentiation toward regional specific neural precursors. STEM CELLS 27:78-87.

List of Publications continuation …                                                             Miodrag Stojkovic

Cervera RP, Gutiérrez NM, Escorihuela E, Moreno R, Stojkovic M (2009). Trichostatin A affects histone acetylation and gene expression on porcine somatic cell nuclear transfer embryos. Theriogenology 72:1097-1110.

Cervera RP, Stojkovic M (2009). Developments and challenges in human embryonic stem cell research in Spain. Stem Cell Reviews and Reports 5:334-339.

Escobedo-Lucea MC, Stojkovic M (2010). Growth of human embryonic stem cells using derivates of human fibroblasts. Methods Mol Biol 584:55-69.

Moreno-Manzano V , Rodriguez-Jimenez FJ , Acena-Bonilla JL , Fustero-Lardies S , Erceg S , Dopazo J , Montaner D , Stojkovic M , Sanchez-Puelles JM (2010). FM19G11, a new HIF modulator, affects stem cell differentiation status. J Biol Chem 285:1333-42.

Tilgner K , Atkinson SP , Yung S , Golebiewska A , Stojkovic M , Moreno R , Lako M , Armstrong L (2010). Expression of GFP Under the Control of the RNA Helicase VASA Permits FACS Isolation of Human Primordial Germ Cells. STEM CELLS 28:84-92.

Ronaghi M , Erceg S , Moreno-Manzano V , Stojkovic M (2010). Challenges of Stem Cell Therapy for Spinal Cord Injury: Human Embryonic Stem Cells, Endogenous Neural Stem Cells or Induced Pluripotent Stem Cells? STEM CELLS 28:93-99.

Cervera RP, Silvestre MA, Martí N, García-Mengual E, Moreno R, Stojkovic M. Effects of diffrent oocyte activation procedures on development and gene expression of porcine pre-implantation embryos. Reproduction in Domestic Animals (in press).

Prado-Lopez S, Conesa A, Armiñán A, Martínez-Losa M, Escobedo-Lucea C, Gandia C, Tarazona S, Melguizo D, Blesa D, Montaner D, Sanz-González S, Sepúlveda P, Götz S, Enrique O’Connor J, Moreno R, Dopazo J, Burks DJ, Stojkovic M (2010). Hypoxia promotes differentiation of human embryonic stem cells to endothelium. STEM CELLS 28:407-418.

Armstrong L, Tilgner K, Saretzki G, Atkinson SP, Stojkovic M, Moreno R, Przyborski S, Lako M (2010).Human induced pluripotent stem cell lines show similar stress defense mechanisms and mitochondrial regulation to human embryonic stem cells. STEM CELLS 28: 661-673.

Lako M, Armstrong L, Stojkovic M (2010). Induced pluripotent stem cells : it looks simple but can looks deceive? STEM CELLS 28:845-850.

Ljujic B, Stojkovic M (2010). Methods for derivation of human embryonic stem cells. Serbian journal of experimental and clinical research 11:25-33.

Santos F, Hyslop L, Stojkovic P, Leary C, Murdoch A, Reik W, Stojkovic M, Herbert M, Dean W. Evaluation of epigenetic marks in human embryos derived from IVF and ICSI. Human Reproduction (in press). 

Talens-Visconti R , Sanchez-Vera I, Kostic J, Perez-Arago MA, Erceg S, Stojkovic M, Guerri C. Neural differentiation from human embryonic stem cells as a tool to study early brain development and the neuroteratogenic effects of ethanol. Stem Cells and Development (in press).

Erceg S, Ronaghi M, Garcia Rosello M, Oria Alonso M, Cordoba J, Perez Arago M, Moreno-Manzano V, Gomez Perez M, Rodriguez-Jimenez FJ, Bhattacharya SS, Stojkovic M. (2010) Transplanted oligodendrocytes and motoneuron progenitors generated from human embryonic stem cells promote locomotor recovery after complete transection of spinal cord injury. (submitted)

Erceg S, Ronaghi M, Zipancic I, Lainez S, Garcia Rosello M Chen Xiong, Moreno-Manzano V, Rodriguez-Jimenez FJ, Planells R, Alvarez-Dolado M, Bhattacharya SS, Stojkovic M (2010). Efficient differentiation of human embryonic stem cells into functional cerebellar neurons (Stem Cell and Development, revision)

Becker-Kojic Z, Stojkovic M. Expression pattern of the novel glycosylphosphatidylinositol anchored surface glycoprotein ACA in human peripheral blood cell (submitted). 

Cervera R, Stojkovic M. Impact of pluripotent stem cells on regenerative therapeutics and drug discovery (submitted).


Stojkovic M, Lako M, Strachan T, Murdoch A. Patent on derivation of human embryonic stem (hES) cells and usage of novel feeder for growth of undifferentiated hES cells (pending PCT WO 2005/080551 A2).

Stojkovic M, IP Title: "Human Embryonic Stem Cells". International Patent Application No PCT/RS2007/000009

Academic Review


FP7 European Commission

DFG-NSFC (Deutsche Forschungsgemeinschaft and National Science Foundation of China)

Human Fertilisation and Embryology Authority (HFEA), UK

European Science Foundation, Strasbourg, France

Connecticut Stem Cell Research, USA

Wellcome Trust, UK


Medical Research Council (MRC), UK

Czech Academy of Science, Czech Republic

The Agency for Science, Technology and Research’s (A*STAR) Biomedical Research Council (BMRC), Singapore

Deutsche Forschungsgemeinschaft (DFG), Germany

Federal Ministry of Education and Research (BMBF), Germany

ISSCR Registry Advisory Group, USA

Alberta Heritage Foundation for Medical Research, Canada

Scientific Journals:

STEM CELLS (Editor since 01/07/2009)

Academic Review continuation…                                                                                Miodrag Stojkovic

PLoS Biology

PLoS Genetics

Nature Methods

Cell Stem Cell

Endocrine Reviews

Journal of Cell Science

Rejuvenation Research

BMC Developmental Biology

Cell Proliferation

Experimental Neurology

Stem Cells and Development

Biotechnology and Bioengineering

British Journal of Pharmacology

Human Reproduction



Scientific Adviser: Therapeutic Human Polyclonals, Tyscon, USA

Agrobiogen GmbH, Laretzhausen, Germany

Edmond de Rothschild Investment Partners, Paris, France

Multifund B.V., AE Rotterdam, The Netherlands

Earlybird Venture Capital, Hamburg, Germany

Invited Lectures                                                                                               12/2003-05/2010         

Stem cells, regenerative medicine and drug development. Invited lecture by Actavis, Belgrade, Serbia 20/05/2010.

Diseases and Stem Cells. Invited lecture, Spanish culture centre Cervantes, Belgrade, Serbia, 30/03/2010 

Preimplantation genetic diagnosis. Invited lecture, News in human reproduction, Society for human Reproduction, Serbia and S.I.S.M.E.R Bologna, Belgrade, 27/11/2009

Artificial gametes. Invited lecture, News in human reproduction, Society for human Reproduction, Serbia and S.I.S.M.E.R Bologna, Belgrade, 27/11/2009

Stem Cells. Invited lecture, CryoSave, Belgrade, Serbia, 14/10/2009

Stem Cells: Future perspectives in infertility treatment. Invited lecture. Serono. Prag, Czech Republic, 03/10/2009.

Directed neuronal differentiation of human embryonic stem cells. Invited lecture, Socieded Espanola de Terpia Genica y Celular Granada, Spain, 01/10/2009.

Complementary stem cells. Invited lecture, Society for Physiology, Kragujevac, Serbia, 18/09/2009

How to publish scientific manuscript? Invited lecture, Nis, Serbia, 18/09/2009

Invited Lectures                                                                                               12/2003-05/2010         

Stem cells. Invited lecture. 4th International Meeting of Medical Students. Novi Sad, Serbia, 18/07/2009.

Ependymal stem cells. Invited lecture by Prof. Il-Hoan Oh. 7th Catholic International Stem Cell Symposium, St. Mary Hall, the Catholic University of  Korea, Seoul, 11/06/2009. 

Stem cells, an overview. Invited lecture by Prof. J. Dai, University of Beijing, National Academy of Science, China, 08/06/2009

Applications of stem cells. Invited lecture, Balliol College, Oxford, 08/05/2009.

Human Pluripotent Stem Cells Symposium. Why do we need embryonic and adult stem cells? Invited lecture by Dr. S. Sulivan and Abcam company, Dublin 23/04/2009.

Aspectos técnicos y científicos de la clonación de células humanas. Invited lecture, Auditorio de Garrigues, Madrid. 27/01/2009.

Understanding embryonic and adult stem cells. 2008 Seoul symposium on stem cell research. Yonsei University, Seoul, Korea. 03/12/2008.

Derivación de células madre especificáis del paciente. Congreso controversias en ginecologia y reproducción. Invited lecture, Valencia, Spain, 28/11/2008.

Artificial gametes: is the future knocking at the front door? 25 years of the IVF laboratory in Maribor. Invited lecture, Maribor, Slovenia, 28/11/2008.

Stem cell therapy in neurosurgery. 11th International Congress of neurosurgery, Nis, Serbia, invited lecture, 10/10/2008.

Adult and embryonic stem cells. Second EFIS/EJI Belgrade symposium/postgraduate course. Inflammation at the Interface of Innate and Acquired Immunity. Belgrade, Serbia, Invited lecture, 20/09/2008

Second International Medical Students' Congress, Novi Sad, Serbia. Embryonic stem cells. Invited lecture, 18/06/2008.

Therapeutic cloning for the treatment of Type 1 diabetes: How far it is? 8th Annual Rachmiel Levine Symposium, Newport Beach, California, 08/01/2008.

Human embryonic stem cells and their applications. Invited lecture, First Emirates-Hellenic Medical Conference, Dubai, 06/12/2007.

Eggs, embryos and stem cells. Invited lecture, Second Annual Translational Stem Cell Research Conference (NYSCF). New York City, 16/10/2007.

Anwendungen von humanen embryonalen Stammzellen: Wahrheit und Verschleierung. Podium discussion. Dresden, Germany, 10/09/2007

Invited Lectures                                                                                               12/2003-05/2010         

Timeless human embryonic stem cells. Invited lecture, SENS (Strategies for Engineered Negligible Senescence, organised by Rejuvenation Research and Aubrey de Grey. Cambridge, UK, 08/09/2007. 

Nuclear transfer for stem cells derivation. Invited lecture. ESHRE, Lyon, France, 01/07/2007

Warum brauchen wir humane Embryonen und humane embryonale Stamzellen? Invited lecture. University of Bonn. Bonn, 08/06/2007.

Human embryonic stem cells in regenerative medicine. Invited lecture. 14th Annual Symposium on Recent Advances in stem cell transplantation. German Cancer Research Centre, Heidelberg, 26/04/2007.

Open debate: Stammzellforschung in Deutschland: Haben wir den Zug verpasst? German Cancer Research Centre, Heidelberg, 25/04/2007.

Stem cells and modern medicine. Invited lecture, Serbian Academy of Science and Art, Branch Novi Sad, 11/04/2007

Stem cell therapy. Invited lecture, Valjevo Hospital, Serbia, 04/04/2007.

Sources and characteristics of human embryonic stem cells. Invited lecture, Columbia University, New York City, USA, 29/03/2007.

Preimplantation human embryos and embryonic stem cells as tools to study human development. Invited lecture StemCONN 07, Connecticut’s Stem Cell Research International Symposium, Hartford, Connecticut, USA, 28/03/2007.

Derivation of hESC. Invited lecture, Science, Society, Cambridge, UK, 01/02/2007.

What is a stem cell? Invited lecture, Charitè Hospital, University of Berlin, Germany, 31/01/20007.

Arrested embryos as source for derivation of hESC. Invited lecture, Innovations in Human Reproduction, Belgrade, Serbia, 08/12/2006.

Biology and differentiation of human embryonic stem cells. Invited lecture, Meeting Computers in Cardiology, Seminars, Valencia, Spain, 17/09/2006.

Nuclear transfer and human embryonic stem cells. Invited lecture, Madrid, Spain, 24/07/2006.

Transnationalisation of stem cell sciences: political, scientific, and commercial strategies in UK and Germany. Invited lecture. German Ministry of Education, Berlin-Brandenburg Academy of Sciences and Humanities, Berlin, Germany, 18/02/2006.

Isolation and culture of human embryonic stem cells. Invited lecture, EESCN, From tissue engineering and regenerative medicine to policy, Cambridge, UK, 19/04/2006.

Medical applications of human embryonic stem cells. Invited lecture, Medical Faculty, Kosovska Mitrovica, Serbia and Montenegro, 07/04/2006.

Invited Lectures                                                                                               12/2003-05/2010          

Nuclear transfer. Possibilities in Regenerative Medicine. Invited lecture, Serono Symposia International Foundation Conference on Therap�

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